Hi Marco,
We have been using Brevo (originally Sendinblue), a third-party email service for some of our bulk emails and automated emails since 2020. It offers us functionality that would take time and resources to manage in-house. We wrote a RIPE Labs article about this a while ago:
https://labs.ripe.net/author/ulka_athale_1/improving-our-emails/Regarding it being an IPv4-only service, unfortunately, this is often the case with email service providers. We have asked Brevo to offer services over IPv6 as well, but without success.
Kind regards,